High-dose pralidoxime for organophosphorus poisoning.
نویسندگان
چکیده
منابع مشابه
Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial.
BACKGROUND The role of oximes for the treatment of organophosphorus pesticide poisoning has not been conclusively established. We aimed to assess the effectiveness of a constant pralidoxime infusion compared with repeated bolus doses to treat patients with moderately severe poisoning from organophosphorus pesticides. METHODS 200 patients were recruited to our single-centre, open randomised co...
متن کاملPralidoxime in Acute Organophosphorus Insecticide Poisoning—A Randomised Controlled Trial
BACKGROUND Poisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year. Although the World Health Organization recommends use of pralidoxime, this antidote's effectiveness remains unclear. We aimed to determine whether the addition of pralidoxime chloride to atropine and supportive care offers benefit. METHODS AND FI...
متن کاملPralidoxime for organophosphate poisoning
From their randomised trial, Kirti Pawar and colleagues report in today’s Lancet on two pralidoxime-dosing schemes in 200 patients who had moderately severe self-poisoning with organophosphorus insecticide. After a 2-g loading dose over 30 min, half received a high-dose regimen of 1 g/h pralidoxime iodide for 48 h. The other half received a lower dose: 1 g/h every 4 h. After 48 h, the lower dos...
متن کاملClinical study of continuous micropump infusion of atropine and pralidoxime chloride for treatment of severe acute organophosphorus insecticide poisoning.
BACKGROUND Our study sought to assess the effectiveness of a constant micropump infusion of atropine and pralidoxime chloride compared with repeated-bolus doses in patients with severe acute organophosphorus insecticide poisoning (AOPP). METHODS A total of 60 patients with severe AOPP, defined as cholinergic crisis with respiratory failure or cerebral edema, were randomly divided into two gro...
متن کاملEffectiveness of High Dose Pralidoxime for Treatment of Organophosphate Poisoning
Background: For effective treatment of organophosphate (OP) poisoning, development of a standardized protocol with flexible dose regimen for atropine and pralidoxime is an essential step. In this study, we aimed to assess the protocol devised in our setting; Bach Mai Hospital Poison Treatment Center, for treatment of OP poisoning that included a higher dose regimen of pralidoxime (2PAM). Method...
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ورودعنوان ژورنال:
- Lancet
دوره 369 9571 شماره
صفحات -
تاریخ انتشار 2007